What is the medical therapy for Waldenström macroglobulinemia?

Updated: Feb 01, 2021
  • Author: Karen Seiter, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

The monoclonal antibody rituximab, as monotherapy or in combination with the alkylating agent bendamustine or a proteosome inhibitor, features prominently in treatment of Waldenström macroglobulinemia. Other drugs used include alkylating agents, purine nucleoside analogs,  immunomodulatory drugs, mammalian target of rapamycin (mTOR) inhibitors, and

Salvage therapy for patients with resistant disease or relapse includes reuse or alternative use of front-line agents, combination therapy, thalidomide (with or without steroids), autologous transplantation, and monoclonal antibody (alemtuzumab).


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