What is the role of combination chemotherapy in the treatment of Waldenström macroglobulinemia?

Updated: Feb 01, 2021
  • Author: Karen Seiter, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Combination chemotherapy approaches have been explored, with response rates of more than 75%. Combinations include the following [44, 45] :

  • Fludarabine plus rituximab
  • Fludarabine plus cyclophosphamide
  • Cladribine plus cyclophosphamide
  • Cladribine plus cyclophosphamide and rituximab
  • Bortezomib, dexamethasone, and rituximab (BDR)
  • R-CHOP (rituximab, cyclophosphamide, doxorubicin [hydroxydaunorubicin], vincristine [Oncovin], prednisone)

The German Low Grade Lymphoma Study Group reported response rates of 69% and 94%, respectively, in 72 patients treated with either CHOP or R-CHOP. [46]


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