Which lab and imaging studies are indicated in the workup of Waldenström macroglobulinemia?

Updated: Feb 01, 2021
  • Author: Karen Seiter, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

General studies include the following:

  • Complete blood count (CBC)
  • Red cell indices
  • Platelet count
  • Peripheral smear

Normocytic normochromic anemia, leukopenia, and thrombocytopenia may be observed. Anemia is the most common finding, being present in 80% of patients with symptomatic Waldenström macroglobulinemia.

Other workup includes the following:

  • Imaging studies are used for assessment of lymphadenopathy, extramedullary disease, or organomegaly.
  • Fundoscopic examination is recommended in all patients with visual disturbance, hyperviscosity symptoms, and/or an IgM level ≥3000 mg/dL. [4]  
  • Patients with findings of peripheral neuropathy should have nerve conduction studies and antimyelin-associated glycoprotein serology. [24]

See also Waldenstrom Macroglobulinemia Staging.


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