What are the cutaneous manifestations of Waldenström macroglobulinemia?

Updated: Feb 01, 2021
  • Author: Karen Seiter, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Skin manifestations include the following:

  • Purpura (see the image below)
  • Bullous skin disease
  • Papules on extremities
  • Cutaneous plaques and nodules
  • Chronic urticaria (Schnitzler syndrome)
  • Raynaud phenomenon
  • Livedo reticularis
  • Acrocyanosis
Purpura from Waldenström macroglobulinemia is evid Purpura from Waldenström macroglobulinemia is evident in the forearm of a 65-year-old man who presented with a purpuric rash on all of his extremities. Although the patient had a history of hepatitis C, the possibility of hepatitis C cryoglobulinemia was excluded because the rash extended well beyond the hands and feet, and blood testing identified a type I cryoglobulinemia. Image courtesy of Jason Kolfenbach, MD, and Kevin Deane, MD, Division of Rheumatology, University of Colorado Denver School of Medicine.

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