What are the complications of Waldenström macroglobulinemia?

Updated: Feb 01, 2021
  • Author: Karen Seiter, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Complications of Waldenström macroglobulinemia include the following:

  • Visual disturbances secondary to hyperviscosity syndrome

  • Diarrhea and malabsorption secondary to gastrointestinal (GI) involvement

  • Renal disease (less common)

  • Amyloidosis of the heart, kidney, liver, lungs, and joints

  • Bleeding manifestations secondary to platelet dysfunction and coagulation factor and fibrinogen abnormalities due to interaction with plasma IgM

  • Peripheral neuropathy

  • Raynaud phenomenon secondary to cryoglobulinemia

  • Increased predisposition to infection due to B-cell dysfunction (disease related) or T-cell dysfunction (therapy related, particularly after nucleoside analogues)

  • Cardiac failure

  • Increased incidence of lymphomas, myelodysplasia, and leukemias

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