How is transfusion-related acute lung injury (TRALI) managed?

Updated: Jan 12, 2021
  • Author: S Gerald Sandler, MD, FCAP, FACP; Chief Editor: Emmanuel C Besa, MD  more...
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Transfusion-related acute lung injury (TRALI) is managed as follows:

  • Immediately discontinue the transfusion while preserving venous access.

  • Patients with mild episodes should respond to oxygen administered by nasal catheter or mask. If shortness of breath persists after oxygen administration, transfer the patient to an intensive care setting where mechanical ventilation can be employed.

  • In the absence of signs of acute volume overload or cardiogenic pulmonary edema, diuretics are not indicated.

  • No evidence exists that corticosteroids or antihistamines are beneficial.

  • Treat complications with specific supportive measures.

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