Which medications in the drug class Anticholinergic Agents are used in the treatment of Motion Sickness?

Updated: Oct 22, 2018
  • Author: Andrew Brainard, MD, MPH; Chief Editor: Selim R Benbadis, MD  more...
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Anticholinergic Agents

Alkaloids with anti-cholinergic properties that are used for the prevention of motion sickness rather than acute treatment.


Scopolamine is most commonly used as a transdermal patch that is applied behind the ear for up to 72 hours, at which point it can be replaced. Transdermal scopolamine is the most effective pharmaceutical for the prevention and treatment of motion sickness. [32, 33] The patch should be applied 4 hours prior to departure. [34]

Oral tablets are also available and should be taken 1 hour prior to departure at their recommended doses. Some experts report the dose can be safely doubled by wearing either two patches or by supplementing the patch with oral scopolamine. [35, 36] Intranasal scopolamine may also work. [37] Scopolamine may also be used in conjunction with antihistamines, although this will increase the chance of the user experiencing side effects.

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