Which medications in the drug class Piperazine Antihistamines are used in the treatment of Motion Sickness?

Updated: Oct 22, 2018
  • Author: Andrew Brainard, MD, MPH; Chief Editor: Selim R Benbadis, MD  more...
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Piperazine Antihistamines

Long-acting piperazine antihistamines generally cause less sedation than other antihistamines.


Mixture of 1:1 salt consisting of 8-chlorotheophylline and diphenhydramine. Believed to be useful, particularly in treatment of vertigo. Diminishes vestibular stimulation and depresses labyrinthine function through central anticholinergic effects. However, prolonged treatment may decrease rate of recovery of vestibular injuries.


Decreases excitability of middle ear labyrinth and blocks conduction in middle ear vestibular-cerebellar pathways. These effects are associated with relief of nausea and vomiting.


Mechanisms of action are not understood. In nausea, and other vertigo symptoms, may have an effect on labyrinthine apparatus, chemoreceptor trigger zone, in addition to central actions.

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