Which medications are used in the treatment of interstitial cystitis/bladder pain syndrome (IC/BPS)?

Updated: Dec 04, 2020
  • Author: Eric S Rovner, MD; Chief Editor: Edward David Kim, MD, FACS  more...
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The goal of pharmacologic therapy in interstitial cystitis is to relieve symptoms. Medication may be administered orally or intravesically. Urinary analgesics include pentosan polysulfate sodium. (One report suggests a beneficial role for oral cimetidine.) Other agents used with less success include the following:

  • L-arginine
  • Nalmefene
  • Anticholinergic agents (eg, oxybutynin, oxybutynin XL, tolterodine [Detrol and Detrol LA])
  • Hyoscyamine
  • Corticosteroids
  • Antispasmodics
  • Immunosuppressives
  • Anti-inflammatory medications
  • Calcium channel blockers

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