What are the indications for sacral neuromodulation in the treatment of interstitial cystitis/bladder pain syndrome (IC/BPS)?

Updated: Dec 04, 2020
  • Author: Eric S Rovner, MD; Chief Editor: Edward David Kim, MD, FACS  more...
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This should only be used as a fourth-line therapy. [93] A 2011 meta-analysis of sacral neuromodulation for chronic pelvic pain showed widely variable response rates and equally variable follow-up times, further questioning the use of this as a therapy for patients with IC/BPS. [94] However, as this has been shown to be a somewhat effective therapy in many patients, and as it is minimally invasive, it may be considered prior to any major invasive surgical interventions. [95]

In addition, sacral neuromodulation has been shown to normalize the abnormally high levels of antiproliferative factor (APF) and the abnormally low levels of heparin-binding epidermal growth factor in the urine of patients with interstitial cystitis.

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