What is the role of hyaluronic acid in the treatment of interstitial cystitis/bladder pain syndrome (IC/BPS)?

Updated: Dec 04, 2020
  • Author: Eric S Rovner, MD; Chief Editor: Edward David Kim, MD, FACS  more...
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Hyaluronic acid glycosaminoglycan replenishment therapy has yielded moderate results in non–placebo-controlled studies. In a study of weekly instillation of a 50-mL solution of phosphate-buffered solution containing 40 mg of sodium hyaluronate, 85% and 84% of patients reported symptomatic and quality-of-life improvement, respectively, with 50% of patients reporting a lasting effect at 5-year follow-up. [81] Patients in this study had demonstrated abnormal results on a modified potassium sensitivity test. Lower response rates are seen in patients without evidence of a urine-tissue barrier abnormality. [81] Currently, several studies with level 2b evidence support hyaluronic acid instillation. Patients report decreases in visual analog pain scores. Multicenter, randomized trials do not exist, however. [82]

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