What is the role of resiniferatoxin in the treatment of interstitial cystitis/bladder pain syndrome (IC/BPS)?

Updated: Dec 04, 2020
  • Author: Eric S Rovner, MD; Chief Editor: Edward David Kim, MD, FACS  more...
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Resiniferatoxin, a capsaicin analogue, is 100-10,000 times more potent than capsaicin and is not associated with severe burning. However, resiniferatoxin has shown poor effectiveness after single administration, with no significant improvement in symptoms of interstitial cystitis, and adverse effects of dose-dependent pain and urgency symptoms. [78] A meta-analysis by Guo et al in 2013 showed that no significant improvement was achieved in patients treated with resiniferatoxin in terms of frequency, nocturia, incontinence, or involuntary detrusor contractions. [79] At this time, the AUA recommends against this treatment. [80]

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