What is the role of pentosan polysulfate sodium in the treatment of interstitial cystitis/bladder pain syndrome (IC/BPS)?

Updated: Dec 04, 2020
  • Author: Eric S Rovner, MD; Chief Editor: Edward David Kim, MD, FACS  more...
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A 6- to 9-month course of pentosan polysulfate sodium (100 mg tid) is followed by a reassessment of interstitial cystitis symptoms. The authors have found that lower doses of this compound are not as effective, but we have not used the higher doses advocated by some authors. Additionally, adverse effects with pentosan polysulfate are dose dependent. One complication, particularly with long-term use, is macular disease, which may impair vision. [74, 75]

We attempt to try single-agent therapy first, moving down the ladder of medications, rather than treating patients with multiple agents from the outset. If conservative measures and medical therapy fail to provide adequate relief, surgical therapy should be considered.

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