What are the diagnostic exclusion criteria for interstitial cystitis (IC)?

Updated: Dec 04, 2020
  • Author: Eric S Rovner, MD; Chief Editor: Edward David Kim, MD, FACS  more...
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The presence of any of the following criteria is intended to exclude patients with other diseases that can cause bladder symptoms and patients with atypical characteristics:

  • Cystometric bladder capacity greater than 350 mL in a conscious patient with either gas or liquid filling
  • Absence of an intense urge to void when patient's bladder has been filled with 100 mL of gas or 150 mL water during cystometry at a fill rate of 30-100 mL/min
  • Demonstration of phasic involuntary bladder contractions on cystometry findings at a fill rate of 30-100 mL/min (note that although this is an exclusion criterion per the NIDDK, detrusor instability may be present in as many as 14% of patients with a clinical diagnosis of interstitial cystitis)
  • Duration of symptoms less than 9 months
  • Nocturia
  • Symptoms relieved by antimicrobials, urinary antiseptics, anticholinergics, or antispasmodics
  • Micturition frequency of less than 8 times daily
  • Diagnosis of bacterial prostatitis or cystitis within a 3-month period
  • Presence of ureteral or bladder calculi
  • Active genital herpes
  • Uterine, cervical, vaginal, or urethral cancer
  • Urethral diverticulum
  • Cyclophosphamide or other chemical cystitis
  • Tuberculous cystitis
  • Radiation cystitis
  • Benign or malignant bladder tumors
  • Vaginitis
  • Age younger than 18 years

It should be noted, however, that strict application of these criteria would have misdiagnosed more than 60% of patients who were diagnosed by researchers as definitely or likely having IC/BPS. [51]

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