What are the National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) diagnostic criteria for interstitial cystitis (IC)?

Updated: Dec 04, 2020
  • Author: Eric S Rovner, MD; Chief Editor: Edward David Kim, MD, FACS  more...
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Because no pathognomonic criteria exist for the diagnosis of interstitial cystitis, the modified National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) criteria for the inclusion of patients in interstitial cystitis basic and clinical research studies can be used. These criteria, initially developed in 1987, were originally intended not to define interstitial cystitis but to ensure that studies of the disease had relatively comparable patient populations. Nevertheless, the criteria became the de facto definition of the disease, although a significant number of patients with interstitial cystitis do not meet the criteria. [42]

The NIDDK criteria for interstitial cystitis include 2 sets of inclusion criteria and 1 of exclusion criteria. For the inclusion criteria, 1 of the cystoscopic findings and at least 1 subjective symptom must be present. All of the exclusion criteria must be absent.

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