Answer
Answer
The definition of "adolescent" may differ depending on the regimen; for regimens with specific definitions of "adolescent," the definition is provided in parentheses following the regimen.
Atazanavir (ATV)
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Age 16-21 years: For antiretroviral-naive patients, give ATV 300 mg PO plus ritonavir (RTV) 100 mg PO with food or ATV 400 mg PO once daily with food [11]
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Antiretroviral-experienced patients: ATV 300 mg PO plus RTV 100 mg PO, both once daily with food
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Dosing recommendations during coadministration with other antiretrovirals: ATV in combination with EFV in therapy-naive patients only (adult dose): ATV 400 mg plus RTV 100 mg PO plus EFV 600 mg PO, all once daily but at separate times (ATV + RTV with food, EFV without food)
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ATV in combination with TDF (adult dose): ATV 300 mg PO plus RTV 100 mg PO plus TDF 300m g PO, all once daily with food
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Only RTV-boosted ATV should be used in combination with TDF, because TDF decreases ATV exposure
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