How do narcotics and protease inhibitors (PIs) interact?

Updated: Jan 15, 2019
  • Author: Jason F Okulicz, MD, FACP, FIDSA; Chief Editor: Michelle R Salvaggio, MD, FACP  more...
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Oxycodone coadministration with LPV/RTV results in a 2.6-fold increase in oxycodone AUC; oxycodone dose reduction may be necessary and monitor for opioid-related adverse effects.

Methadone coadministration with boosted PIs may result in lower methadone levels; opioid withdrawal may occur but unlikely; dose adjustment of methadone not usually required but monitor for symptoms of opioid withdrawal.

Methadone use with unboosted ATV does not require dose adjustment.

Methadone coadministration with unboosted FPV may result in lower methadone levels; monitor and titrate methadone as clinically indicated.

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