How does St. John's wort and protease inhibitors (PIs) interact?

Updated: Jan 15, 2019
  • Author: Jason F Okulicz, MD, FACP, FIDSA; Chief Editor: Michelle R Salvaggio, MD, FACP  more...
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Coadministration of St. John’s wort and PIs is contraindicated; St. John’s wort can significantly decrease PI drug concentrations.

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