How do benzodiazepines and protease inhibitors (PIs) interact?

Updated: Jan 15, 2019
  • Author: Jason F Okulicz, MD, FACP, FIDSA; Chief Editor: Michelle R Salvaggio, MD, FACP  more...
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Alprazolam or diazepam in combination with all PIs may increase benzodiazepine levels; use alternatives such as lorazepam, oxazepam, or temazepam, which have a decreased potential for interaction because of non-CYP450 metabolic pathways.

Avoid combination of midazolam or triazolam with PIs.

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