What causes drug interactions with protease inhibitors (PIs) interact?

Updated: Jan 15, 2019
  • Author: Jason F Okulicz, MD, FACP, FIDSA; Chief Editor: Michelle R Salvaggio, MD, FACP  more...
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Potential for drug interactions should be considered when selecting antiretroviral therapy (ART) for patients with human immunodeficiency virus (HIV) infection. Drug interactions with antiretrovirals are commonly caused by the inhibition or induction of hepatic drug metabolism. [1, 2] Protease inhibitors in combination with other drugs may require dose adjustments or should be avoided because of potential drug interactions.

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