What causes drug interactions with antiretroviral therapy?

Updated: Jul 12, 2021
  • Author: Shahab Qureshi, MD, FACP; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Answer

Possible drug-drug interactions should be taken into consideration when selecting an antiretroviral (ARV) regimen. A detailed review of concomitant medications can help in creating a regimen that minimizes undesirable interactions. The potential for drug interactions should be assessed when any new drug (including over-the-counter agents) is added to an existing ARV regimen. Most drug interactions with ARV drugs are mediated through inhibition or induction of hepatic drug metabolism. [1] The mechanisms of drug interactions with each ARV is briefly mentioned below. Please refer to the content below [2] for lists of significant drug interactions with different ARV agents and recommendations on contraindications, dose modifications, and alternative agents.


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