Which lab test findings suggest primary mediastinal B-cell lymphoma (PMBCL)?

Updated: Sep 14, 2019
  • Author: Sonali M Smith, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Laboratory studies are not diagnostic of PMBL, but over 70% of patients can have elevated lactate dehydrogenase (LDH) levels. By definition, patients do not have bone marrow involvement, and 75-80% of patients are usually staged as having stage I or II disease. Most patients present with bulky disease defined as a mass greater than 10 cm in largest diameter.

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