What is the role of bone marrow aspiration in the diagnosis of follicular lymphoma?

Updated: Mar 03, 2020
  • Author: Lauren C Pinter-Brown, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Answer

Although a diagnosis of follicular lymphoma can be established based on histologic findings from lymph nodes and involvement of the bone marrow can be diagnosed using morphologic criteria, cytogenetic analysis of bone marrow cells should be performed because the t(14;18) chromosomal translocation is found in the majority of patients with follicular lymphoma and can help establish the diagnosis. Fluorescence in situ hybridization (FISH) testing for a t(14;18) chromosomal translocation may also be useful.


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