How is follicular lymphoma treated?

Updated: Mar 03, 2020
  • Author: Lauren C Pinter-Brown, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Answer

Treatment varies based on the stage of the disease. Early-stage, localized disease may be treated with radiation therapy or excision in certain cases. Observation is recommended for patients with advanced disease until they develop systemic symptoms or disease that threatens organ function.

Multiagent chemotherapy in combination with rituximab is the most common first-line treatment strategy for follicular lymphoma. Combination chemotherapy regimens vary and include the following:

  • Rituximab, cyclophosphamide, vincristine, prednisone (R-CVP) [7]

  • Rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone (R-CHOP) [8]

  • CHOP immediately followed by tositumomab/iodine-131 radioimmunotherapy (CHOP-RIT) [9]

  • Bendamustine plus rituximab [10]

  • Rituximab plus lenalidomide [11] (non-chemotherapeutic regimen)


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