What is the role of lab tests in the workup of mantle cell lymphoma (MCL)?

Updated: Mar 15, 2019
  • Author: Muhammad Rashid Abbasi, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Blood studies may yield the following results in mantle cell lymphoma (MCL):

  • Complete blood count: Anemia and cytopenias are secondary to bone marrow infiltration; lymphocytosis of more than 4000/µL occurs in 20-40% of cases

  • Serum chemistry: Elevation of lactate dehydrogenase levels correlates with tumor burden

  • Liver function tests: Abnormal findings result from liver involvement

  • Beta2-microglobulin: An elevated level indicates a poor prognosis

  • Gamma globulin: Hypogammaglobulinemia or monoclonal gammopathy are rare findings

  • Coombs test: Rarely positive

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