What are the recommendations for empiric treatment of septic arthritis of prosthetic joints?

Updated: Oct 06, 2020
  • Author: John L Brusch, MD, FACP; Chief Editor: Michael Stuart Bronze, MD  more...
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Unless the clinical situation demands (ie, clinical sepsis), a culture should be obtained before initiating antibiotic therapy for PJI. [11]

Duration of antibiotic therapy is at least 6wk; some patients require indefinite antibiotic treatment.

Rifampin 600 mg PO q24h should be added for staphylococcal infections if the hardware is retained. To prevent the development of resistance, rifampin should be started 2 days following initiation of antibiotic therapy. [1, 2, 3, 4, 5]

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