What is the role of splenectomy in the treatment of chronic immune thrombocytopenia (ITP) in children?

Updated: Nov 30, 2019
  • Author: Perumal Thiagarajan, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Because of the likelihood of spontaneous remission, splenectomy should be avoided if possible. Furthermore, splenectomy in patients younger than 6 years is associated with severe postsplenectomy sepsis. The American Society of Hematology recommends splenectomy for children only if they have had ITP longer than 1 year and their bleeding results in platelet counts below 30,000/µL. [16] If treatment with corticosteroids, IVIG, or anti-D has been successful, these agents may be used prophylactically while waiting for a possible spontaneous remission.

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