How do drugs cause thrombocytopenia?

Updated: Nov 30, 2019
  • Author: Perumal Thiagarajan, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
  • Print


Drugs can induce thrombocytopenia by a number of mechanisms. [9] For example, the cytotoxic drugs can inhibit platelet production in the bone marrow, as can thiazide diuretics, interferon, and alcohol.

More commonly, drug-induced thrombocytopenia results from the immunologic destruction of platelets. Drugs can induce antibodies to platelets, either acting as a hapten or as an innocent bystander. In addition, drugs such as gold salts and interferon can induce an ITP-like disorder.

Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!