What is the role of antidepressants in the development of suicidal behaviors?

Updated: Jul 26, 2021
  • Author: Stephen Soreff, MD; Chief Editor: Glen L Xiong, MD  more...
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Initially, the FDA and studies linked antidepressants to childhood and adolescent self-destructive events and required a warning for those populations; however, Schneeweiss and colleagues found the same linkage for adults as well. [7]

The investigators reviewed data from all 287,543 residents of Canada's British Columbia, 18 years or older, who had been placed on an antidepressant between 1997 and 2005 and concluded the following: "Our finding of equal event rates across antidepressant agents supports the US Food and Drug Administration's decision to treat all antidepressants alike in their advisory. Treatment decisions should be based on efficacy, and clinicians should be vigilant in monitoring after initiating therapy with any antidepressant agent." [7]

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