What is the ACTG classification system for Kaposi sarcoma (KS) staged?

Updated: Mar 09, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Edwin Choy, MD, PhD  more...
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The ATCG criteria had not previously been systematically assessed in sub-Saharan African patients. In a study of Ugandan adults with HIV-associated Kaposi sarcoma, Okuku et al reported that systemic symptoms were strongly associated with death in the early period after Kaposi sarcoma diagnosis, while tumor status was most predictive of death in the 4-24 month period. [5]

Those staging schemes may or may not correlate well with the presentation and outcomes in the many HIV-infected children in sub-Saharan Africa who have Kaposi sarcoma. [6] Pediatric Kaposi sarcoma has distinctive features compared with Kaposi sarcoma in adults. [7, 8] Lymph node involvement is more common in children, with marked immunosuppression linked with the highest mortality risk. Hence, a pediatric-specific staging classification has been proposed. [9]  

In addition, detection of gastrointestinal Kaposi sarcoma is important for staging. Endoscopic biopsy utilizing hematoxylin and eosin staining, lymphatic and blood vessel endothelial cell markers, and human herpesvirus 8 (HHV-8) staining has demonstrated high diagnostic accuracy (>0.80), with its accuracy increasing with endoscopic tumor staging. [11]

T staging is being utilized, as noted below. [14]

Table. ACTG Classification System (Open Table in a new window)


Tumor (T)

Extent of tumor

T0 (good risk)

Kaposi sarcoma is confined to skin and/or lymph nodes and/or demonstrates minimal oral disease (roof of mouth); the Kaposi sarcoma lesions in the mouth are flat rather than raised

T1 (poor risk)

Kaposi sarcoma lesions are widespread; one or more of the following is present:

  • Edema (swelling) due to the tumor

  • Extensive oral Kaposi sarcoma: nodular lesions (raised) and/or lesions in areas of the mouth besides the palate

  • Lesions of Kaposi sarcoma are in organs other than the lymph nodes (eg, lungs, intestine, liver)

Immune system (I)

Status of the immune system, as measured by CD4 cell levels

I0 (good risk)

CD4 cell count is ≥200/µL (normal range, 600-1500/µL); more recent studies have used counts of either 150 or 100/µL

I1 (poor risk)

CD4 cell count is </td></tr>

Systemic illness (S)

Extent of involvement within the body or systemic illness

S0 (good risk)

No systemic illness present; all of the following are true:

  • No history of opportunistic infections or thrush

  • None of the following B symptoms is present: unexplained fever, night sweats, >10% involuntary weight loss, diarrhea persisting for >2wk

  • Karnofsky performance status score is ≥70 (ie, patient is up and about most of the time and able to take care of him- or herself)

S1 (poor risk)

Systemic illness present; one or more of the following is true:

  • History of opportunistic infections or thrush

  • One or more B symptoms is present

  • Karnofsky performance status score <70

  • Other HIV-related illness is present (eg, neurologic disease or lymphoma)

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