What are the treatment options for unresectable or metastatic melanoma following ipilimumab treatment?

Updated: May 05, 2020
  • Author: Winston W Tan, MD, FACP; Chief Editor: Dirk M Elston, MD  more...
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Answer

Answer

Treatment options for unresectable or metastatic melanoma and disease progression following ipilimumab treatment are as follows:

  • Pembrolizumab 200 mg IV q3wk over 30 min until disease progression or unacceptable toxicity; if BRAF V600 mutation positive, a BRAF inhibitor (dabrafenib, vemurafenib) [27]

  • Nivolumab 240 mg IV q2wk or 480 mg IV q4wk over 30 min until disease progression or unacceptable toxicity; if BRAF V600 mutation positive, a BRAF inhibitor [28]


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