What is the risk for hereditary breast cancer?

Updated: Apr 23, 2020
  • Author: Joseph A Sparano, MD; Chief Editor: John V Kiluk, MD, FACS  more...
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See the list below:

  • Approximately 5% of all breast cancers are attributable to a heritable mutation, including BRCA1/2 or other less common genetic mutations [63] ; factors associated with a higher likelihood of having a mutation include diagnosis before the age of 50y (especially before 40y), bilateral disease, family history in ≥ 2 first-degree relatives, family history of ovarian cancer, or Ashkenazi Jewish descent

  • Algorithms are available to estimate the likelihood of an individual with breast cancer harboring a mutation, including those from Myriad Genetics, Inc. (www.myriad.com), BCRAPRO (www.stat.duke.edu/~gp/brcapro.html), and other models; it is recommended that testing begin with a family member diagnosed with breast cancer rather than with unaffected individuals

  • High-risk patients should be provided with information on genetic testing (http://www.cancer.gov/cancertopics/pdq/genetics/breast-and-ovarian/HealthProfessional) and should be referred for genetic counseling

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