How is inoperable noninflammatory locally advanced breast cancer treated?

Updated: Apr 23, 2020
  • Author: Joseph A Sparano, MD; Chief Editor: John V Kiluk, MD, FACS  more...
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Answer

Answer

Treatment includes chemotherapy, with or without a taxane. Regimens are as follows:

  • TAC: Docetaxel (Taxotere) 75 mg/m2 IV on day 1 plus  doxorubicin (Adriamycin) 50 mg/m2 IV on day 1 plus  cyclophosphamide 500 mg/m2 IV on day 1 every 3 wk for six cycles or

  • Dose-dense AC-P: Doxorubicin 60 mg/m2 IV plus  cyclophosphamide 600 mg/m2 every 2wk for four cycles, followed by paclitaxel 175 mg/m2 every 2 wk with colony-stimulating factor (CSF) support (more effective than the 3-wk schedule in ER/PR-negative disease) [8] or

  • AC: Doxorubicin 60 mg/m2 IV plus  cyclophosphamide 600 mg/m2 IV on day 1 every 3 wk for four cycles


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