What is included in long-term monitoring of acute promyelocytic leukemia (APL)?

Updated: Jul 02, 2019
  • Author: Sandy D Kotiah, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Disease monitoring: Bone marrow biopsy should not be done until count recovery (40-50d after induction), because remission can take up to 40-50d

Relapse monitoring: Check quantitative PML-RAR alpha PCR, [12] cytogenetics, and fluorescence in situ hybridization (FISH) for 15;17 translocation from the bone marrow at the end of consolidation treatment, then monitor peripheral blood quantitative PML-RAR alpha PCR every 3mo for 2y; the assay can be performed every 3-6mo for the next 3y; if a positive test result is obtained, repeat PCR testing from bone marrow in 2-4wk

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