What is the Programa para el Tratamiento de Hemopatias Malignas (PETHEMA) consolidation therapy regimen for the treatment of acute promyelocytic leukemia (APL)?

Updated: Jul 02, 2019
  • Author: Sandy D Kotiah, MD; Chief Editor: Emmanuel C Besa, MD  more...
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PETHEMA regimen:

  • First cycle: idarubicin 5 mg/m2 IV bolus on days 1-4

  • Second cycle: mitoxantrone 10 mg/m2 IV bolus on days 1-3

  • Third cycle: idarubicin 12 mg/m2 IV bolus for 1 dose

  • ATRA administered concurrently with cycles above: ATRA 45 mg/m2/day (25 mg/m2/day for patients < 20y) in 2 divided doses for 15d with each 4-wk cycle of chemotherapy (especially for intermediate- and high-risk patients)

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