What are the protocols on blood bank support in the treatment of acute lymphoblastic leukemia (ALL)?

Updated: Jul 02, 2021
  • Author: Karen Seiter, MD; Chief Editor: Matthew C Foster, MD  more...
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Answer

Answer

Blood bank support:

  • Patients should receive leukodepleted, irradiated blood products to reduce the risk of transfusion-associated graft versus host disease, cytomegalovirus (CMV) transmission, and febrile transfusion reactions.

  • Most patients are anemic and require red cell transfusion support.

  • Patients usually receive packed red cells when the hemoglobin level falls below 8 g/dL.

  • Patients with significant respiratory and cardiac disease might require transfusion at a higher hemoglobin level.

  • Patients are frequently thrombocytopenic; platelet transfusions are indicated when the platelet count is < 10,000/mm3.

  • Patients being seen less than daily will receive platelet transfusions at a higher threshold (20,000/mm3).

  • Patients with active bleeding will be transfused to a platelet count of 50,000/mm3; patients with CNS hemorrhage should be transfused to a platelet count of 100,000/mm3.


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