What medications are used for inpatient pyelonephritis empiric therapy?

Updated: Nov 04, 2020
  • Author: Mony Fraer, MD, MHCDS, FACP, FASN; Chief Editor: Thomas E Herchline, MD  more...
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Patients with pyelonephritis who require hospitalization should be treated with one of the IV antimicrobial regimens listed below. The treatment of choice should be based on local resistance data, and the drug regimen should be tailored according to susceptibility results. IV therapy should be given for 24-48 h or until severe symptoms improve. Duration of therapy, inclusive of initial IV therapy,  should be as follows:

  • Ciprofloxacin: 7 d
  • Levofloxacin: 5 d
  • Beta-lactams: 10-14 d.

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