Which medications are used in second-line outpatient pyelonephritis empiric therapy?

Updated: Nov 04, 2020
  • Author: Mony Fraer, MD, MHCDS, FACP, FASN; Chief Editor: Thomas E Herchline, MD  more...
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Second-line empiric therapy is with trimethoprim/sulfamethoxazole 160/800 mg (Bactrim DS, Septra DS) 1 tablet PO BID for 14d. If trimethoprim is used when the susceptibility is not known, an initial single IV dose of one of the following may also be given:

  • Ceftriaxone 1 g IV
  • Gentamicin 7 mg/kg IV
  • Tobramycin 7 mg/kg IV
  • Amikacin 20 mg/kg IV

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