What are the serologic assays for diagnosing and managing hepatitis C (HCV) infection?

Updated: Jul 14, 2021
  • Author: Joel Schifter, MD; Chief Editor: Eric B Staros, MD  more...
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Answer

Answer

These tests detect antibodies to HCV (anti-HCV) and are used for screening and diagnosing HCV infection. Results are reported as anti-HCV positive or negative values. They have very high sensitivity and specificity for HCV detection (sensitivity of greater than 99%, specificity of 99% in immunocompetent patients).

A negative test is sufficient to exclude a diagnosis of chronic HCV infection in immune-competent patients. Those on hemodialysis and patients with immune deficiencies may have false-negative results, whereas false-positives may occur in patients with autoimmune disorders. [1, 2]


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