What are the clinical and lab poor prognostic factors for chronic myelogenous leukemia (CML)?

Updated: May 23, 2021
  • Author: Emmanuel C Besa, MD; Chief Editor: Sara J Grethlein, MD, FACP  more...
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Poor-prognosis characteristics include the following clinical and laboratory factors:

  • Older age

  • Symptomatic presentation

  • Poor performance status

  • African-American descent

  • Hepatomegaly

  • Splenomegaly

  • Negative Philadelphia chromosome or BCR/ABL

  • Anemia

  • Thrombocytopenia

  • Thrombocytosis

  • Decreased megakaryocytes

  • Basophilia

  • Myelofibrosis (increased reticulin or collagen)

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