What acute symptoms indicate immediate evaluation in cases of occupational exposure to HIV?

Updated: Jul 27, 2020
  • Author: Ana Elizabeth Markelz, MD, FACP, FIDSA; Chief Editor: John Bartlett, MD  more...
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Symptoms of acute HIV (fever, sore throat, lymphadenopathy, rash, flu-like symptoms, and weight loss) should prompt immediate evaluation. For patients who receive PEP, CBC, renal, and hepatic function should be rechecked at 2 and 4 weeks.

Table 3. Monitoring Recommendations After Initiation of PEP Regimens Following Occupational Exposurea [16] (Open Table in a new window)



Week 1

Week 2

Week 6

Week 16

Clinic visit

√  72 hours




Pregnancy test





Serum liver-associated enzymes, renal function, CBC countb




HIV testc



a See also Hepatitis C and Hepatitis B Immune Globulin (HBIG).

b CBC count should be obtained in all exposed workers at baseline; a follow-up CBC count is indicated only in those receiving a zidovudine-containing regimen.

c Recommended even if PEP is declined. If a fourth-generation HIV test is not used, the testing schedule should be 6 weeks, 12 weeks, and 6 months.

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