What is the recommended postexposure prophylaxis (PEP) regimen for occupational exposure to HIV?

Updated: Jul 27, 2020
  • Author: Ana Elizabeth Markelz, MD, FACP, FIDSA; Chief Editor: John Bartlett, MD  more...
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Three-drug PEP regimens are now the recommended regimens for all exposures owing to the safety and tolerability of new HIV drugs. The guidelines no longer require assessing the severity of exposure. There are some special circumstances, however, in which a 2-drug regimen can be used, especially when recommended antiretroviral medications are unavailable or there is concern about potential adherence problems or toxicity. An expert should be consulted if a 2-drug PEP regimen is being considered.

The preferred HIV 3-drug PEP regimen is raltegravir (Isentress) 400 mg PO twice daily plus Truvada (tenofovir DF 300 mg/emtricitabine 200 mg) 1 PO once daily

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