What are the histologic characteristics of metaplastic breast cancer (MBC)?

Updated: May 24, 2018
  • Author: Peter Abdelmessieh, DO, MSc; Chief Editor: Marie Catherine Lee, MD, FACS  more...
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Metaplastic breast cancer (MBC) accounts for less than 1% of breast cancer cases, tends to occur in older women (average age of onset in the sixth decade), and has a higher incidence in blacks. It is characterized by a combination of adenocarcinoma plus mesenchymal and epithelial components.

MBC encompasses a wide variety of histologic patterns, including the following:

  • Spindle-cell carcinoma
  • Carcinosarcoma
  • Squamous cell carcinoma of ductal origin
  • Adenosquamous carcinoma
  • Carcinoma with pseudosarcomatous metaplasia
  • Matrix-producing carcinoma

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