What is the histologic triad of medullary carcinoma of the breast?

Updated: May 24, 2018
  • Author: Peter Abdelmessieh, DO, MSc; Chief Editor: Marie Catherine Lee, MD, FACS  more...
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Medullary carcinomas appear commonly in a younger patient population, and are more frequent in women who have BRCA1 gene mutations. These tumors have a more favorable prognosis that infiltrating ductal carcinoma. Most patients present with a bulky palpable mass with axillary lymphadenopathy. Diagnosis of this type of breast cancer depends on the following histologic triad:

  • Sheets of anaplastic tumor cells with scant stroma
  • Moderate or marked stromal lymphoid infiltrate
  • Histologic circumscription or a pushing border


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