When are screening tests for hypercoagulable states indicated in the workup of transient ischemic attack (TIA)?

Updated: Dec 03, 2018
  • Author: Ashish Nanda, MD; Chief Editor: Andrew K Chang, MD, MS  more...
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Screening for hypercoagulable states (particularly in younger patients with no known vascular risk factors) may be performed, though this practice is not evidence-based. Tests include the following [1] :

  • Protein C, protein S, and antithrombin III activities

  • Activated protein C resistance/factor V Leiden

  • Fibrinogen

  • D-dimer

  • Anticardiolipin antibody

  • Lupus anticoagulant

  • Homocysteine

  • Prothrombin gene G20210A mutation

  • Factor VIII

  • Von Willebrand factor

  • Plasminogen activator inhibitor-1

  • Endogenous tissue plasminogen activator activity

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