Which medications in the drug class Antibiotics are used in the treatment of Abdominal Hernias?

Updated: Jul 01, 2021
  • Author: Assar A Rather, MBBS, MD, FACS; Chief Editor: John Geibel, MD, MSc, DSc, AGAF  more...
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Antibiotics are to be used if the patient has a strangulated hernia. Broad-spectrum antibiotics, most commonly ampicillin and gentamicin, should be given in cases of gastroschisis and patients with large omphalocele.

Cefoxitin (Mefoxin)

Multiple regimens that address bowel perforation or ischemic bowel can be used. Cefoxitin provides coverage for both aerobic and anaerobic gram-negative bacteria.


Gentamicin is an aminoglycoside antibiotic used for gram-negative bacterial coverage. It is commonly used in combination with an agent against gram-positive organisms and one that covers anaerobes. The drug is used in conjunction with ampicillin for prophylaxis in patients with open surgeries.

Dosing regimens are numerous and are adjusted based on creatinine clearance (CrCl) and changes in volume of distribution. Gentamicin may be given intravenously or intramuscularly.


Ampicillin is used along with gentamicin for prophylaxis in patients with open surgeries. It interferes with bacterial cell wall synthesis during active replication, causing bactericidal activity against susceptible organisms.

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