What risks are associated with topical treatments for omphalocele (abdominal hernia)?

Updated: Jul 01, 2021
  • Author: Assar A Rather, MBBS, MD, FACS; Chief Editor: John Geibel, MD, MSc, DSc, AGAF  more...
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Grob introduced the use of merbromin as an escharotic for scarifying the intact sac of a giant omphalocele. However, the development of mercury poisoning terminated its use. Chemical dressings using silver sulfadiazine (which has leukopenia as a complication), povidone-iodine solution (hypothyroidism as a complication), 0.5% silver nitrate solution (argyrism as a complication), and gentian violet have served as agents to protect against infection while the sac epithelializes.

In current practice, only life-threatening associated conditions, poor probability of survival in infants, or failure of better means of coverage warrant use of these methods. A large residual ventral hernia results, which may be problematic because of loss of domain.

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