What is gastroschisis and how does it occur?

Updated: Jul 01, 2021
  • Author: Assar A Rather, MBBS, MD, FACS; Chief Editor: John Geibel, MD, MSc, DSc, AGAF  more...
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Gastroschisis is thought to be the result of a failure of the umbilical coelom to develop to an appropriate size. The intestine then ruptures out of the body wall to the right of the umbilicus, where a slight weakness exists secondary to resorption of the right umbilical vein early in gestation (see the image below). Gastroschisis is associated with intestinal atresias in 10-15% of cases, probably as a consequence of interruption of the vascular supply to the intestine.

In this baby with gastroschisis, bowel is uncovere In this baby with gastroschisis, bowel is uncovered and presents to right inferior aspect of cord.

Experimentally, administration of the insecticide methylparathion has produced gastroschisis. Transplacental transmission of such teratogens helps explain gastroschisis in siblings with different fathers.

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