How does acquired elastase deficiency lead to increased incidence of abdominal hernias?

Updated: Jul 01, 2021
  • Author: Assar A Rather, MBBS, MD, FACS; Chief Editor: John Geibel, MD, MSc, DSc, AGAF  more...
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Acquired elastase deficiency also can lead to increased hernia formation. In 1981, Cannon and Read found that the increased serum elastase and decreased alpha1 -antitrypsin levels associated with smoking contribute to an increased rate of hernia in heavy smokers. The contribution of biochemical or metabolic factors to the creation of inguinal hernias remains a matter for speculation.

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