Which medications in the drug class Anxiolytics, Benzodiazepines are used in the treatment of Local Anesthetic Toxicity?

Updated: Jan 09, 2019
  • Author: Raffi Kapitanyan, MD; Chief Editor: David Vearrier, MD, MPH  more...
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Answer

Anxiolytics, Benzodiazepines

These agents terminate seizures. By binding to a specific receptor site, these agents appear to potentiate the effects of gamma-aminobenzoic acid (GABA) and to facilitate inhibitory GABA neurotransmission and other inhibitory neurotransmitters.

Diazepam (Valium, Diastat, Diastat AcuDial)

Diazepam depresses all levels of the CNS (eg, limbic and reticular formation), possibly by increasing the activity of GABA. Diazepam diminishes or terminates seizures. Individualize dosage and increase cautiously to avoid adverse effects.

Midazolam

Midazolam depresses all levels of the CNS (eg, limbic and reticular formation), possibly by increasing activity of GABA. It diminishes or terminates seizures. Midazolam is shorter acting and more potent than diazepam. Individualize dosage and increase cautiously to avoid adverse effects.


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